10 Random Questions
Which of the following statements concerning neuroleptic malignant syndrome is true?
(A) It does not respond to dantrolene therapy
(B) It is inherited as an autosomal trait
(C) It is not triggered by succinylcholine
(D) It occurs after long-term use of L-dopa
(E) The halothane-caffeine contracture test is negative in susceptible patients
Reveal Answer
ADVANCED
Pharmacology & Pharmacokinetics
General
Left ventricular subendocardial perfusion pressure is best estimated by the difference between
(A) mean arterial and central venous pressures
(B) diastolic arterial and pulmonary artery occlusion pressures
(C) mean arterial and pulmonary artery occlusion pressures
(D) systolic arterial and pulmonary artery occlusion pressures
(E) diastolic arterial and central venous pressures
Reveal Answer
BASIC
General
A 30-year-old man who is undergoing laparotomy and resection of a large kidney tumor has a decrease in SpO2 from 100% to 92% and an increase in peak airway pressure from 20 to 35 cm H2O. Plateau pressure is unchanged at 18 cm H2O. Which of the following is the most likely cause?
(A) Abdominal packing
(B) Inadequate anesthesia
(C) Inadequate muscle relaxation
(D) Obstruction of the endotracheal tube
(E) Pneumothorax
Reveal Answer
BASIC
Equipment & Physics
Respiratory & Critical Care
General
A 1150-g, 10-day-old infant is undergoing a bowel resection for necrotizing enterocolitis. Heart rate is 200 bpm and blood pressure measured through a femoral artery catheter is 45/24 mmHg. The most appropriate next step is administration of
(A) calcium gluconate
(B) epinephrine
(C) esmolol
(D) fentanyl
(E) normal saline solution
Reveal Answer
ADVANCED
Pediatric
Which of the following statements concerning the volume of distribution of a drug is true?
(A) It is equal to the sum of the volumes of the tissue spaces into which it diffuses
(B) It is equal to the volume to which it is distributed outside the plasma volume
(C) It is unaltered by the amount bound to red blood cells and plasma proteins
(D) It depends on elimination from plasma
(E) It relates the total amount of the drug in the body to the plasma concentration
Reveal Answer
BASIC
Pharmacology & Pharmacokinetics
During controlled ventilation, which of the following will cause an increase in end-tidal carbon dioxide tension with a normal waveform on the capnograph?
(A) Bronchospasm
(B) Rapid blood loss
(C) Ventricular fibrillation
(D) Endobronchial migration of the endotracheal tube
(E) Release of a thigh tourniquet
Reveal Answer
BASIC
General
Which of the following attenuates the most common cardiovascular side effect of protamine administration?
(A) Pretreatment with a diuretic
(B) Pretreatment with a prostaglandin inhibitor
(C) Pretreatment with a pulmonary vasodilator
(D) Injection via the distal lumen of the pulmonary artery catheter
(E) Slow peripheral intravenous injection
Reveal Answer
The shorter duration of action of alfentanil relative to fentanyl is due to its
(A) greater lipid solubility
(B) increased clearance
(C) increased rate of hepatic metabolism
(D) lesser protein binding
(E) smaller volume of distribution
Reveal Answer
Compared with thiopental, methohexital is characterized by
(A) better absorption after rectal administration
(B) greater protein binding
(C) greater hepatic clearance
(D) larger volume of distribution
(E) more complete biotransformation
Reveal Answer
BASIC
Pharmacology & Pharmacokinetics
Normal pregnancy is associated with a decrease in each of the following EXCEPT
(A) expiratory reserve volume
(B) FEV1/FVC ratio
(C) functional residual capacity
(D) thoracic compliance
(E) vital capacity
Reveal Answer
ADVANCED
OB