A patient with jaundice who has a minimally elevated SGOT (AST), markedly elevated alkaline phosphatase, and normal prothrombin time is to receive a muscle relaxant. Which of the following is most likely in this patient?
During frontal craniotomy for removal of an astrocytoma, the surgeon notes that the brain is "tight." The patient is receiving nitrous oxide 50% in oxygen, isoflurane 0.5%, fentanyl, and pancuronium. Heart rate is 92 bpm, blood pressure is 110/60 mmHg, end-tidal carbon dioxide tension is 31 mmHg, and oxygen saturation is 98%. The most appropriate initial treatment is to
(A) administer a beta-adrenergic blocker
(B) administer thiopental
(C) decrease isoflurane concentration
(D) decrease mean arterial pressure to 60 mmHg
(E) increase alveolar ventilation
E
Compared with epidural administration of hydrophilic opioids, epidural administration of lipophilic opioids is associated with
(A) earlier onset of pruritus
(B) greater motor block when combined with local anesthetics
(C) higher incidence of delayed respiratory depression
(D) lesser sensitivity to reversal of analgesia by naloxone
A 76-year-old man has a leaking abdominal aortic aneurysm. His blood pressure and pulse have remained stable for 15 minutes at 90/60 mmHg and 130 bpm, respectively. His hemoglobin concentration is 11 g/dl, and the EKG shows a left bundle branch block. Induction of anesthesia should proceed
(A) after a pulmonary artery catheter has been inserted and the pulmonary artery occlusion pressure is greater than 7 mmHg
(B) when the pulse has decreased below 130 bpm from the rapid transfusion of blood
(C) when systolic blood pressure has increased to more than 120 mmHg from the rapid infusion of lactated Ringer's solution
(D) immediately on arrival in the operating room
(E) when circulatory signs deteriorate or cease to improve with rapid volume expansion
One hour after induction of anesthesia for a posterior fossa craniotomy using opioid, relaxant, and nitrous oxide, the brain begins to protrude through the dura. The most effective measure to decrease intracranial pressure is to