A 27-year-old man with type I von Willebrand's disease requires internal fixation of an open fracture of the femur. Prothrombin time, partial thromboplastin time, and platelet count are normal. During surgery, there is significant oozing from the wound and the surgeon notes poor clot quality. The most appropriate therapy at this time is administration of
Each of the following factors decreases uterine blood flow EXCEPT
Which of the following drugs increases cerebral blood flow while decreasing cerebral metabolic rate?
Each of the following values is associated with acute tubular necrosis EXCEPT
Which of the following is more likely to occur with use of trimethaphan to induce hypotension than with use of nitroprusside?
During active labor, 10 ml of bupivacaine 0.5% with epinephrine 1:200,000 is administered epidurally. Fifteen minutes later, maternal blood pressure is 70/50 mmHg and heart rate is 70 bpm; fetal heart rate is 90 bpm for 45 seconds, with loss of beat-to-beat variability. The most likely explanation for the fetal vital signs is
Twelve hours after an uneventful hysterectomy with lidocaine epidural anesthesia, a 70-year-old woman has partial paralysis of the lower extremities. She is receiving morphine 0.5 mg/hr through an epidural catheter and is pain free. On examination, definite motor loss is noted in the lower extremities, but no other deficits are apparent. The most appropriate action at this time is to
Percutanous cordotomy is being considered for a patient with severe pain that has persisted for three months after amputation of the arm for osteogenic sarcoma. Which of the following statements is true?
Which of the following is an effect of metoclopramide?
A 62-year-old woman with obesity and type II diabetes mellitus is scheduled to undergo vitrectomy of the right eye. Five minutes after retrobulbar injection with 0.75% bupivacaine 4 ml and intravenous administration of fentanyl 50 ju-g and midazolam 1 mg, she is apneic and unresponsive. Which of the following is the most likely cause?